Monday, 2 April 2018

Scientists discover promising off-switch for inflammation



Scientists have discovered a new metabolic process in the body that can switch off inflammation. They found that ‘itaconate’ – a molecule derived from glucose – acts as a powerful off-switch for macrophages, which are the cells in the immune system that lie at the heart of many inflammatory diseases.
“It is well known that macrophages cause inflammation, but we have just found that they can be coaxed to make a biochemical called itaconate,” said Luke O’Neill from Trinity College, Dublin in Ireland.

“This functions as an important brake, or off-switch, on the macrophage, cooling the heat of inflammation in a process never before described,” O’Neill said. The discovery, published in the journal Nature, is very much on the frontier of inflammation research and the researchers are now exploring its relevance to the onset and development of inflammatory and infectious diseases. They are also keen to explore whether the findings can be exploited in the effort to develop new anti-inflammatory medicines.

“The macrophage takes the nutrient glucose, whose day job it is to provide energy, and surprisingly turns it into itaconate,” said Evanna Mills from Trinity College, Dublin. “This then blocks production of inflammatory factors, and also protects mice from the lethal inflammation that can occur during infection,” Mills said.


'Roseanne' returns with monster TV ratings in Trump era





Sunday, 1 April 2018

Rakul Preet Singh slammed by Sri Reddy and Maadhavi Latha




While women of Tollywood are telling their casting couch horror stories, Rakul Preet is in constant denial about it. Speaking at an event to condemn the abusive language of a popular regional news channel about actresses, she said that she never had such experiences so far in Telugu film industry and maintained that casting couch doesn't exist in Tollywood. 
Slamming the 'Spyder' actress, Maadhavi Latha and Sri Reddy said that Rakul is painting a pretty picture of the Telugu film industry and is refraining from speaking the truth out of fear of losing out on opportunities. Maadhavi went on to suggest that Rakul should create awareness for young actresses rather than denying its existence. Sri Reddy went on to say that she can even release the names of the filmmakers involved in casting couch as a proof. 
This is not the first time Rakul has asserted that she never had such experiences. According to her, 'topics like casting couch are discussed and debated more because there is more masala there'. In a previous interview with us, she said, "In India, we find something interesting and we start talking about it for six months and then we forget about it. There are a lot more important and bigger things to be spoken about I feel. People forget the rapes that happen. Topics like casting couch are discussed and debated more because there is more masala there. Having said that, I feel that the basic human nature is that of an opportunist. One cannot do anything about it and it is a male dominated world. 

TV actor Vikram Sharma to debut in Bollywood



TV actor Vikram Sharma is set to mark his Hindi film debut with a yet-to-be-titled horror film.
Vikram can be currently seen as Balwinder Singh in Discovery Jeet’s “21 Sarfarosh: Saragarhi 1897”.
The film is directed and produced by Ajay Yadav.
“It’s like a dream come true. Every actor’s wish is to grow and want to be a part or Bollywood. I have done many roles in past which help me, all the roles that I have played till date has a getup be it Hanuman or now as Balwinder Singh in ’21 Sarfarosh: Saragarhi 1897′,” said Vikram in a statement.
“This is for the first time I can be me and show myself to the audience and it feels good to look great and its a nice feeling all together. It is just the start, it’s a new story and is different. I had put all my hardwork in it and my martial arts has helped me alot in fight sequences. I did all my action sequences by myself without and body double,” added Vikram.
On the small screen, Vikram has worked in projects like “Ramayan”, “Sankat Mochan Mahabali Hanuman”, “Razia Sultan” and “Ganga”.The Statesman.

Zlatan caps off MLS debut with brilliant goals




Zlatan Ibrahimovich showed his mettle in his MLS debut as his two goals –including a 40-yard volley in an entertaining game, helped LA Galaxy to a 4-3 victory against Los Angeles FC.
He scored with the imperious volley only six minutes after coming on as a substitute before an injury-time header to seal victory for the MLS outfit in his debut game.
The script of the match was befitting of Ibra’s new Hollywood home and LAFC had raced to a 3-0 lead within 60 minutes with Zlatan still on the bench. Some slack play from LAFC had allowed Galaxy to pull one goal back before the crowd roared in appreciation as Ibra made his entrance.
The Swede made an immediate impact, drawing defenders away and allowing Chris Pontius space to score from a header to make the score 3-2.
"If you look back, every team I came to, the first official game I scored. I said I would not let it down today, I will score also today," Ibrahimovic said. "I was just waiting to come in because when you’re losing 3-0 the adrenaline is pumping even more because you want to be able to do something, help the team, especially when they’re in a difficult situation. I just wanted to come in.
"The fans were demanding Zlatan, and I gave them Zlatan."
Zlatan’s 40-yard strike made it 3-3 as the crowd erupted in joy. It was a fairy-tale strike and teammate Perry Kitchen remarked: "My original thought was: ‘He’s not shooting this. Is he really going to shoot this?’"

Eggs can be dangerous to health




Personally, I find the thought, of eating an egg, revolting. It is the period blood of a hen and, if you break the egg and expose it to air for a few minutes, it will smell the same as the blood on a sanitary towel.
Why would I want to add cholesterol to my daily diet?

But eggs are used in so many things that, even if you don’t eat them directly, you probably will be ingesting them in some form.

Egg shells are powdered and used for fortification of breads and confectioneries, fruit drinks, crackers, condiments. If you see “fortified” on any of these—or glazing on bread—know that this is egg. Egg membrane protein is used as an ingredient in many cosmetics as a softener.

Egg yolks are used in shampoos and conditioners and, sometimes, soaps. Cholesterol, lecithin, and some of the egg’s fatty acids, are used in skin care products, such as revitalisers, make-up foundations and even lipstick.

Louis-Désiré Blanquart-Évrard invented a process using albumen, in 1850, for photographic printing in the 19th century. Paper was laid on a mixture of albumen and salt. When it dried, it made a glossy coated paper. It was so popular that commercial producers of paper kept chickens on site!

Painters used eggs as binders for applying pigments. The pigment colour was produced by ground-up materials found in nature-everything, from lapis lazuli to the tiny bodies of scale insects, was crushed and mixed with egg yolk to produce egg tempera.

Egg albumen is still used by artists as a binder for pigments, as an ingredient of waterproof glue, and as a varnish Avidin is a protein of egg white. It is extensively used in biotechnological applications, particularly in medical diagnostics, as in the Elisa test.

Lysozyme, an enzyme found in egg white, is used for the ripening of certain European-type cheeses. Lysozyme inhibits the growth of Clostridium tyrobutyricum – a bacterium which can be present as a contaminant in milk.

A more recent use of lysozyme is in wine preparation as a substitute for sulphites. Lysozyme is used in processed foods to extend the shelf life by inhibiting or destroying spore-forming organisms.

Lysozyme is used as an antimicrobial agent in pharmaceutical products.
Liposomes, fatty droplets found in eggs, are used as a controlled delivery mechanism for various drugs. Immunoglobulin yolk (IGY), a simple egg-yolk protein, is used as an anti-human-rotavirus (HRV) antibody in food products.

Shell-membrane protein is being used experimentally to grow human skin connective tissue cells for severe-burn victims and, in Japan, is being used in cosmetics (Antigen specific immunoglobulins (IgYs) from eggs are planned to be used for preventing dental caries: candies, chocolates and gums containing anti-Streptococcus mutans (a bacteria involved in tooth decay) from eggs have been used in Japan.

Ovotransferrin or Conalbumin is another protein of egg white which has been used to remove iron from drinking water. Ovalbumin is the predominant protein in egg white and is utilised in the diagnostic industry.

For more than forty years, fertile eggs have been used as a culture medium for the influenza virus to produce vaccines. The influenza virus is injected into the developing embryo. For three days it multiplies in the egg.

The egg is then broken, the fluid extracted and the virus used as vaccine. Egg yolk is added to agar cultures to grow microorganisms bred in laboratories. Fertile eggs are used to preserve bull semen for artificial insemination.

Egg white has been used in the manufacture of edible packing films, for ingredients in the food, chemical and pharmaceutical industries
It is eggs in food that are the biggest problem for a vegetarian. Pastas and bread, confectionery – most of them have egg in them.

In fact, make sure you buy unglazed bread. Sponge cakes, meringues or soufflés have whisked egg white. Eggs bind loose crumbly ingredients together, so they are used in patties, croquettes, fritters and fillings. Whipped egg is used as a thickening agent in pie fillings, custard sauces and baked custard.

Mayonnaise is made of egg yolk. Pastries use egg white in the crusts. Eggs are put in commercial ice creams, baby food, sauces and dairy products . Egg powders are a key ingredient in meat production (sausages, hamburgers, hams) as well as vegetarian preparations (soya sausages, hamburgers).

Avoiding eggs and meat has become a minefield. Irresponsible and insensitive, so called scientists work with egg industries to find newer ways to use their product. Tall claims are made, but the amount of suffering that is caused is unimaginable.

For instance, work is underway to genetically alter chickens so that they produce eggs containing a large quantity of human serum albumin (HSA), a protein used in saline drips in hospitals. Currently the protein is taken from human blood plasma. Using transgenic chicken, research is also being done by commercial companies to produce egg antibodies to combat hepatitis and cancer.

It has been claimed by the egg industry itself that the content of the egg can be changed by simply changing the diet of the hen. This is what they say: “With adjustments to the diets of the laying hen the profile of fatty acids, fat-soluble vitamins, and minerals such as iodine, fluorine, manganese, and B vitamins, can be changed.

Using a flax-based diet or rapeseed or fish oils in the feed, eggs can be enriched with omega-3 and omega-6 fatty acids. Vitamin E in eggs can be added as well as iodine levels. Research is being done to add conjugated linoleic acids (CLAs).”

If this is true, then the rubbish fed to hens in India – cardboard, powdered granite, dead mashed bodies of other hens, pesticides like fipronil, to name a few ingredients , must have had the effect of making eggs almost valueless or dangerous to health. Our FSSAI should investigate the quality of eggs on the market.

Bangladesh plans to change English spellings of five districts



The proposed spellings are Chattagram (for Chittagong), Barishal (for Barisal), Kumilla (for Comilla), Jashore (for Jessore) and Bagura (for Bogra).
The suggestions will be placed at a meeting of the National Implementation Committee for Administrative Reorganisation-Reform or NICAR on Monday, said Cabinet Secretary Md Shafiul Alam.
Prime Minister Sheikh Hasina will preside over the meeting at her office.
NICAR works to reorganise districts, sub-districts, police stations, form new ministries, divisions, form and reform different administrative units with the prime minister as its convener.

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